There is no uniform plan for the management of patients with metastatic lesions within the humerus. Any plan has to be tailored to each individual patient due to a variety of factors, including the clinical presentation, stage of disease, general condition, together with the skills and resources of the clinical team. Satisfactory management requires a multidisciplinary team approach, including an orthopedic surgeon, medical oncologist, radiation oncologist, pathologist and other support services. We report a case of a multiple tumor metastasis within the humerus, complicated by a pathological fracture of the distal humerus, treated with a combined ipsilateral shoulder and elbow arthroplasty using a custom interlocking prosthesis. The postoperative course was uneventful and the patient showed excellent functional and clinical improvement.